2025 NFL season · Week 16

NFL Games on Monday, December 22, 2025

There is 1 NFL game on Monday, December 22, 2025 (Week 16).

All games are final; scores are shown below.

Last updated: Oct 3, 2026, 6:02 PM ETSchedule data: third-party sports data feedTV listings: listed by our data provider (may be incomplete)

Games and TV coverage

Monday NightMon, Dec 22 · 8:15 PM ET · 1 game · Standalone window

8:15 PM ETFinal
San Francisco 49ers48
Indianapolis Colts(home)27
7:15 PM CT · 6:15 PM MT · 5:15 PM PT
Lucas Oil Stadium · Indianapolis, Indiana
TV (listed): ABC, ESPN, ESPN 2, ESPN Deportes, NFL Sunday Ticket
Standalone windowGame details: San Francisco 49ers at Indianapolis Colts